Frequently Asked Questions

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Care World

We’ve brought together the most commonly asked questions on general care topics and answered them clearly and concisely for you.

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Hair

Which hair color makes you look younger?

Which hair color makes the face look more vibrant?

Which hair color makes you look older?

Who is suitable for hair transplantation?

What should be applied to the hair before using Dyson Airwrap?

What is the correct order of hair care products?

How can I make my hair grow faster?

What is hair porosity?

How do chemical treatments increase porosity?

How does heat (straighteners, curling irons, blow dryers) affect porosity?

Skincare

What should be the basic steps of a skincare routine?

Can I choose products without knowing my skin type?

How often should peeling be done?

Why is the skin barrier discussed so much?

Which active ingredients are currently the most popular?

Is it safe to use products with multiple active ingredients at the same time?

Aesthetic & Care Procedures

What are the differences between PDRN and mesotherapy?

Application method and depth

Effect profile: depth, speed, and intensity

Facial Rejuvenation: Botox, Fillers & Baby Botox

What are energy-based treatments?

What are regenerative aesthetic treatments?

HIFU vs Radiofrequency (RF): Effectiveness Comparison

What is NAD⁺ and what does it do in the skin?

DefinitionNAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells and plays a critical role in cellular energy production, DNA repair, and stress response.As NAD⁺ levels naturally decline with age, this decrease is associated with reduced skin repair capacity, loss of elasticity, and visible signs of aging.Key benefits for the skinDNA repair & photoagingNAD⁺ is an essential cofactor for DNA repair enzymes, especially PARPs. It supports the repair of DNA damage caused by UV exposure and environmental stressors, helping reduce photoaging, pigmentation, and potentially contributing to skin cancer prevention mechanisms.Cellular energy & regenerationMitochondria require NAD⁺ to produce ATP. Adequate NAD⁺ levels enhance energy production and renewal in keratinocytes and fibroblasts, resulting in skin that appears more refreshed, plump, and revitalized.Collagen, elasticity & wrinklesStudies suggest that increasing NAD⁺ levels supports collagen and elastin synthesis, helping reduce fine lines, wrinkles, and loss of elasticity while improving overall skin firmness and tightness.Barrier function & hydrationBy supporting protein and lipid synthesis, NAD⁺ strengthens the epidermal barrier, reduces transepidermal water loss, alleviates dryness and sensitivity, and promotes smoother, more resilient skin.Antioxidant & anti-inflammatory effectsNAD⁺ supports antioxidant systems and longevity-associated proteins such as sirtuins, helping reduce oxidative stress and inflammation. This contributes to decreased redness, dullness, and early aging signs.Topical NAD⁺ and its precursors (Niacinamide, NMN, NR)Direct NAD⁺ vs precursorsBecause NAD⁺ is difficult to deliver topically in a stable and effective form, many formulations use precursors such as NMN (nicotinamide mononucleotide), NR (nicotinamide riboside), or niacinamide, which the skin can convert into NAD⁺.NiacinamideIn addition to its well-known benefits—barrier strengthening, reduction of pigmentation and redness—niacinamide is one of the most well-studied NAD⁺ precursors, supporting the skin’s own NAD⁺ production.Topical NAD⁺ skincare productsNext-generation NAD⁺ and NAD⁺-booster products are marketed as “cellular-level anti-aging” solutions targeting fine lines, loss of elasticity, barrier weakness, and dull skin tone.While current clinical data is promising, research on topical NAD⁺ derivatives is still in early stages, with most evidence coming from mechanistic and small-scale studies.

Is NAD more effective in topical or oral form?

Short answer: Based on current evidence, “oral > topical” is more accurate for increasing NAD⁺ levels, while for skin appearance, the two approaches are best viewed as complementary tools. Neither is a miracle on its own, but when combined thoughtfully, they form a strong longevity-focused strategy.There is currently no definitive evidence to claim that one form of NAD⁺ is universally superior. Systemic (oral/IV) and topical applications work at different levels, and available data suggest that a combination approach is the most rational option for skin health.1. Topical NAD⁺ / NAD⁺ PrecursorsAdvantagesTopical products—especially those containing niacinamide, NR, or NMN—are applied directly to the target area and can improve barrier function, hydration, and fine lines.For niacinamide in particular, clinical studies show improvements in elasticity, as well as reductions in hyperpigmentation and redness.In localized anti-aging routines, topical NAD⁺ support can be positioned alongside gold standards such as retinoids and vitamin C.LimitationsPure NAD⁺ is a large, charged molecule with poor penetration through the stratum corneum, and additional challenges such as stability (heat, light, pH) further limit its effectiveness in topical form.For this reason, many experts currently consider formulations with niacinamide, NR, or NMN (NAD⁺ precursors) to be a more practical and evidence-based choice.2. Oral NAD⁺ Precursors (NR, NMN, etc.)AdvantagesOral NAD⁺ precursors—particularly NR and NMN—are the most extensively studied forms and have been shown in human studies to significantly increase blood NAD⁺ levels.This systemic increase may support energy metabolism and DNA repair across multiple tissues, including the skin.Expert reviews suggest that, in terms of evidence-to-cost balance, oral precursors are currently the most rational systemic option for well-aging and overall skin quality.LimitationsClinical data directly linking increased blood NAD⁺ levels to visible reductions in wrinkles or pigmentation in human skin are still limited. Most benefits are inferred indirectly via improvements in cellular energy, inflammation, and aging biomarkers.3. Which is “more effective”?Scientific perspectiveCurrent evidence indicates that oral NAD⁺ precursors (NR/NMN) are more effective than topical pure NAD⁺ in raising NAD⁺ levels, with stronger bioavailability data.On the topical side, products formulated with niacinamide, NMN, or NR, supported by advanced delivery systems, show promising—but still limited—evidence for improving barrier function and photoaging.Practical, skin-focused approachCurrent expert consensus generally recommends:Oral NAD⁺ precursors for whole-body anti-aging, energy support, and indirect skin benefitsTopical formulas containing niacinamide / NMN / NR for localized concerns such as wrinkles, barrier weakness, and uneven toneCombining both with proven actives like retinoids, vitamin C, and sunscreen

What are scalp & “skinification” actives?

Which actives support hair growth, hair loss control & density?

What are the trending actives for hair hydration, shine, and damage repair?

How does AI and personalized skincare work?

What technologies and platform types are used?

What are the key AI-powered skincare trend themes for 2025?

How is the future of skincare changing?

What are science-driven dermocosmetics and the “less but better” approach?

How will energy-based devices and injectable skincare evolve in the future?

References / Sources Used

1. Skincare Trends & Active Ingredients (2025)

https://feelthechange.com.tr/blog/2025-cilt-bakim-trendleri
https://www.wellicita.com/blog/icerik/2025in-en-cok-konusulan-cilt-bakim-aktifleri
https://pemvia.com/blog/cilt-bakimi-trendleri-2025-en-yeni-ve-etkili-cilt-bakim-urunleri
https://oem-cosmetic.com/en/blog/2025-skincare-ingredient-trends-which-emerging-ingredients-are-worth-watching
https://cosmedica-skincare.com/blogs/news/10-skincare-trends-in-2025-ingredients-that-will-transform-your-glow-game
https://trilogylaboratories.com/trending-skin-care-ingredientshttps://www.blog.selfnamed.com/articles/trending-skincare-ingredients

2. Retinol vs. Retinal

https://www.lesielle.com/
https://jijivishacosmetics.com
https://medik8.com.tr/pages/retinal-vs-retinol-which-is-better-for-your-skin

3. PDRN (Salmon DNA) & Mesotherapy

https://vionine.com/blogs/vionine-blog

https://welcometoclub.com/blog/somon-dna-pdrn-nedir
https://rixincosmetics.com/tr/blog/pdrn-skincare/
https://celmade.co/tr/blogs/blog/what-is-polydeoxyribonucleotide-pdrn
https://www.wonder-aesthetics.com/injectors-journal/the-science-behind-pdrn-salmon-sperm-dna-for-microneedling-and-mesotherapy-a

4. Medical Aesthetics & Energy-Based Devices (2025)

https://www.amplify-aesthetics.com/blog/aesthetic-treatment-trends-2025
https://pmc.ncbi.nlm.nih.gov/articles/PMC10917599/

5. NAD⁺ & Longevity Skincare

https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/
https://www.womenshealthmag.com/uk/beauty/skin/a46504210/nad-skincare/
https://www.medik8.com/pages/what-is-nad-the-scientific-skincare-breakthrough
https://www.paulaschoice.com/ingredient-dictionary/ingredient-nicotinamide-adenine-dinucleotide.html
https://pubmed.ncbi.nlm.nih.gov/39513906/

6. Dermocosmetics Market & Future Reports

https://www.mordorintelligence.com/industry-reports/dermocosmetics-skin-care-products-market
https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/a-close-look-at-the-global-beauty-industry-in-2025
https://www.wgsn.com/en/blog/beauty-2030-4-trends-redefining-future-longevity

7. AI, Dermatology & Personalized Skincare

https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2025.1660356/full
https://doralhw.org/innovations-in-dermatology-in-2025-you-should-know-about/
https://www.radiantdermtx.com/post/the-future-of-ai-in-dermatology